30 July, 2009

Swine Flu Vaccine - Priorities Wrong?

In the current edition of Nature (30 July 2009) there is a short correspondence from Italian immunologists on the subject of a swine flu vaccine.

I think it conveys an important message.

In the piece entitled "Flu: vaccinate to cut risk of chimaeric virus emerging", Ilaria Capua & Giovanni Cattoli from the Istituto Zooprofilattico Sperimentale delle Venezie in Italy, make the suggestion that any decisions on priority distribution of swine flu vaccine should take into account areas at higher risk of the emergence of a reassortment virus. This is a virus containing an assortment of genes from various different viruses and can occur in geographic locations where different human and animal viruses are simultaneously present

There is a risk of generating novel influenza A viruses through reassortment of the eight genes that result in antigenic shift, which would give rise to strains to which the human population has no immunity. For example, reassortment occurred between avian and human influenza viruses to create the human pandemic viruses of 1957 and 1968

Developing countries are breeding grounds for these types of reassortment viruses due to inadequate security and safety measures. Based on this, the authors indicate that along with the vaccination of risk patients and healthcare workers, emphasis should be placed on vaccinating populations in developing countries.

Fast-tracking vaccination of humans against pandemic influenza in developing countries where zoonotic flu in poultry is endemic would help prevent reassortment between naoH1N1 or other novel pandemic influenza strains and avian influenza viruses. That would deflect the unpredictable and serious consequences of viral reassortment to humankind worldwide.

So it is vital that we think on a bigger scale here. Undoubtedly each government has prioritised the vaccination of it's own citizens (here in Ireland they are apparently buying two doses per person), however the global community needs to think outside the box and firstly prevent the emergence of reassortment viruses. This constitutes a far greater risk to the human race and must be addressed immediately.

Show Some Support for Simon Singh!!

From Pharyngula.

(Note: this is the infamous article on chiropractic that got Simon Singh sued. It is being reposted all over the web today by multiple blogs and online magazines.)

Some practitioners claim it is a cure-all, but the research suggests chiropractic therapy has mixed results - and can even be lethal, says Simon Singh.

You might be surprised to know that the founder of chiropractic therapy, Daniel David Palmer, wrote that "99% of all diseases are caused by displaced vertebrae". In the 1860s, Palmer began to develop his theory that the spine was involved in almost every illness because the spinal cord connects the brain to the rest of the body. Therefore any misalignment could cause a problem in distant parts of the body.

In fact, Palmer's first chiropractic intervention supposedly cured a man who had been profoundly deaf for 17 years. His second treatment was equally strange, because he claimed that he treated a patient with heart trouble by correcting a displaced vertebra.

You might think that modern chiropractors restrict themselves to treating back problems, but in fact some still possess quite wacky ideas. The fundamentalists argue that they can cure anything, including helping treat children with colic, sleeping and feeding problems, frequent ear infections, asthma and prolonged crying - even though there is not a jot of evidence.

Read More...

27 July, 2009

Thunderf00t vs Comfort

Here is the long awaited debate/discussion between YouTube heavyweight Thunderf00t (red t-shirt) and creationist Ray Comfort (blue shirt).



Round 1: Thunderf00t definitely had the better of the first part, mainly because he's doing all the talking. Thunderf00t 1-0 Ray

Round 2: Here I think Ray does a bit better. Not because he makes any good points, but because Thunderf00t gets bogged down on the painter-painting analogy without really making his point succinctly. This makes him look slightly unsure of what he's saying, although I doubt that's the case. When the conversation turns to morality, Thunder00t seems more assured in what he's saying. Still very little from Ray. Thunderf00t 2-0 Ray

Round 3: OK Ray starts to talk a bit more here. Unfortunately, Thunderf00t shows his inexperience of this form of debate and misses a lot of opportunities to pin him down. When the discussion goes back to morality Ray does the typical creationist thing and uses the extreme example of a child being raped. Thunderf00t's response is not the angle I would have taken. I think Ray gains in confidence here. Thunderf00t 2-1 Ray

Read More...

23 July, 2009

The Impact of Immunology on Human Welfare

As part of our daily lives we are constantly exposed to an extensive array of pathogens, such as bacteria, viruses and parasites. These microscopic invaders tirelessly attempt to gain entry into the cells, tissues and organs of our bodies – and yet despite this relentless barrage of germs, symptomatic disease is relatively uncommon. Key to this defence is the immune system. Over the years the combined efforts of immunologists, in understanding how the immune system functions, have impacted significantly on human welfare.

Vaccination, for example, is commonplace today; we can safely immunise both children and adults against a variety of viruses. For this, we owe a debt of gratitude to early immunologists, such as Edward Jenner and Louis Pasteur, who pioneered the development of vaccines, consequently leading to the eradication of smallpox. Whilst the number of lives that have been saved through vaccination is surely beyond comprehension, the annual influenza vaccine alone is estimated to be 70-90% effective at preventing hospitalisations from influenza complications according to the US Centers for Disease Control and Prevention.

Increased understanding of the causes of organ rejection was another significant impact of immunological research on human life, as it paved the way for successful transplantation medicine thus prolonging the lives of countless otherwise condemned patients. Specifically, the realisation that cell, tissue or organ rejection is due to a host versus graft immune response proved critical.

On a broader scale, the generation of monoclonal antibodies (MAbs), usually produced by immune cells to detect pathogens, has assisted researchers to study protein function, impacting on a diverse range of biological sciences. MAb techniques are still widely used today and their contribution to biological research, not to mention their extensive use in medical intervention, cannot be underestimated.

However, despite the continuing success stories, one area of research in need of a significant breakthrough is autoimmunity. This topic covers a number of disorders in which the body fails to discriminate ‘self’ from ‘non-self’ and consequently attacks host cells in the absence of pathogenic signals. Whilst a lot of progress has been made in several autoimmune disorders, such as rheumatoid arthritis and systemic lupus erythematosus, the underlying mechanisms causing these diseases are still unknown. As such, treatment invariably involves symptomatic relief rather than preventing disease pathogenesis.

One of the major problems in preventing autoimmunity is the inevitable unwanted side effects of potential treatments. Current strategies involve dampening the immune response in affected individuals, which treats the symptoms of autoimmunity but also leaves the patient severely immunocompromised and at risk of infection. This conundrum leads to a patient also being prescribed antibiotics and antivirals, along with their side-effects, to counteract the diminished immunity. Researchers are currently trying to bypass this problem by specifically targeting immune cells involved in autoimmune disorders, namely activated Th1 and Th17 cells, whilst sparing other uninvolved immune cells, allowing patients to maintain an adequate defence against infection. Further work is required, but it seems there may be light at the end of the autoimmune tunnel.

22 July, 2009

Highlights from Nature (Jul 16th 09)

In the current edition of Nature:


-The Schistosoma japonicum genome reveals features of host–parasite interplay

-The genome of the blood fluke Schistosoma mansoni

-The active form of DNA polymerase V is UmuD′2C–RecA–ATP

-Contamination of the asteroid belt by primordial trans-Neptunian objects

-Manipulation of photons at the surface of three-dimension
al photonic crystals

-Photoconductance and inverse photoconductance in films of functionalized metal nanoparticles

-Evidence for middle Eocene Arctic sea ice from diatoms a
nd ice-rafted debris

-Migration of the subtropical front as a modulator of glacial climate


-Global patterns of speciation and diversity

-Evolution of a malaria resistance gene in wild primates


-Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

-A conserved ubiquitination pathway determines longevity in response to diet restriction

-A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning

-The AP-1 transcription factor Batf controls TH17 differentiation

-Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus


I've briefly commented on the highlighted studies below the fold




Read More...

09 July, 2009

Father Ted Was Fiction, Right...?

Most days I'm proud to be Irish.

Some days I'm not...


It has been 14 years since her last major apparition in Ireland, but the Virgin Mary is back and this time in the lowly form of a tree stump in Limerick...

This time more than 2,000 people have signed a petition to prevent the stump’s removal, while hundreds of worshippers have been gathering to recite decades of the rosary and to light candles. Nightly prayer vigils are being held.


At least there's one sensible person down in Limerick though:

Asked what he saw in the stump Mr Reddin replied: ”I see it as the grain of a tree myself.”

07 July, 2009

A&E Homeopathy Style

06 July, 2009

Fermat's Last Theorem

I'm no mathematician. However there is something that has always intrigued me about the purity of mathematical proof. That is why I tend to read a lot of popular science books on maths. An excellent example is Simon Singh's book detailing the events behind the proof to Fermat's Last Theorem.

We all know Pythagorus' Theorem, it was drilled into us at school:


a^2 + b^2 = c^2\!\,


This equation is true when c is the hypoteneuse of a triangle and a and b are the other two sides. It's a straightforward enough mathematical concept and has been proved many times in completely different ways. Indeed, as a child, I was taught a number of the more easily understandable methods.

Now...replace the number 2 in the above equation with n>2 (that is any number greater than 2) and replace the equals sign with a 'does not equal' sign. This is known as Fermat's Last Theorem and can be summarised as:

If an integer n is greater than 2, then the equation an + bn = cn has no solutions in non-zero integers a, b, and c.


In principle, this makes the equation no more difficult to understand. Essentially, you can split a square number into a sum of two lower square numbers, but you can't do the same for cube number or higher powers. Easy enough.

Should be simple enough to prove right?

Wrong.

Read More...

01 July, 2009

Public Acceptance of Evolution

A poll on public knowledge and acceptance of evolution across several countries can be found on the Guardian website.

The British Council has asked, with the help of Ipsos MORI, over ten thousand adults across ten countries from China to the USA, just what they think of evolution.

The results show that the majority of adults surveyed have heard of Charles Darwin and know at least a little about his theory of evolution. But they also show that there are significant minorities of people who either want nothing to do with evolution - and think it should either not be taught in schools or alongside creationism.


Here are the results:

BELIEFS IN EVOLUTION

All figures in %.

Countries
Heard of Darwin
Agree the scientific evidence for evolution exists
Think evolution should NOT be taught, only other theories
Argentina 86 44 6
China 90 55 19
Egypt 38 8 8
Great Britain 91 51 6
India 62 38 13
Mexico 91 52 9
Russia 93 39 13
South Africa 27 8 12
Spain 72 39 7
USA 84 33 9


Nothing new here really. There are a few interesting results though. The Chinese population has the highest acceptance of evidence for the theory of evolution (55%) and one of the highest scores for public knowledge of Darwin (90%), yet 19% of Chinese people think evolution should not be taught, as opposed to say Egypt or South Africa where only 8% and 12% are against teaching evolution respectively, even though 92% of Eygptians and South Africans do not agree that the evidence supports it.

Assuming there are no mistakes in how the data was presented, that seems a bit strange. What's going on in China...?