21 May, 2009

Axioms and Absolute Truth

Have you ever found yourself drawn into a debate with a presuppositionalist? If not, count yourself lucky. It is surely one of the most painful experiences known to man. It is basically the adult equivalent of a child repeatedly asking 'but why?'.

What happens in a debate is the presupper will sooner or later get to the question 'how do you know X?'. You might answer 'I know X because of Y', but the crafty presupper will ask 'how do you know Y?. You might answer 'I know Y because of Z', but the crafty presupper will ask.......well you get it......it could go on for ever.

What eventually happens is that you get to a stage in the debate where you need something as a foundation for your knowledge, e.g. if Z is self-evidently true then it is perfectly fine for you to declare that you know Y and X. The presupper would not be able to question this because your answer for 'how do you know Z?' would be 'Z is axiomatic and so is self-evidently true'. This axiom is God as far as the presupper is concerned, and based on this they will claim that they have an avenue to certainty. On hearing this, you might feel the need to provide your own axiom. The question is what are possible axioms for the non-presupper?

Call true T and absolutely A. and a Statement S. S=T describes a true statement describing a statement as absolutely true would be S=T+A for this to be true A=0 if a has no value it is a non valid qualifier if A>0 then you have a contradiction T+A does not =T so you have a false statement.

To sum if A=0 then there is no reason to call something absolutely true, so therefore a statement can not be absolutely true it can only be true or false.

If A>0, for instance if if the term absolute adds meaning then an absolutely true statement is false because the qualifier absolute makes it non true. So again in this instance a statement is not absolutely true it is simply true.


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20 May, 2009

Are men going extinct?

I'm going to a lecture tonight by Prof Jennifer Graves of the Australian National University entitled 'The Decline and Fall of the Y Chromosome and the Future of Men'. Should be interesting. I'll update tomorrow. Here is the ad:

'The Decline and Fall of the Y Chromosome and the Future of Men'

Delivered by

Professor Jennifer Graves

(PhD, FAA Director, ARC Centre of Excellence for Kangaroo Genomics Head, Comparative Genomics Research Group Research School of Biological Sciences The Australian National University Canberra, ACT 2601, AUSTRALIA)

On Wednesday 20th May 2009

at 7pm

To celebrate Charles Darwin's 200th year anniversary, the 2009 Public Lecture Series will focus on the theme Evolution featuring renowned leader in the Australian and international cell biology, genetics and genomics communities Professor Jennifer Graves. Jenny is particularly well known for her theories of the origin and evolution of human sex chromosomes and sex determining genes, and her dire prediction that the Y chromosome will disappear! the topic of this current lecture. We are delighted and privileged to welcome Professor Jennifer A. Marshall Graves to our college.


~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


Well it was very interesting...

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14 May, 2009

Nature review: Origin of 'RNA world'

OK this is cool. Really cool. But I suck at chemistry so I'm gonna keep it real simple...

It's a given that life somehow emerged at least once on this planet about 4-4.5 billion years ago. Understanding how this amazing event happened is a major challenge though. There are a multitude of theories out there but problems tend to arise in trying to reproduce the origin of life event in the lab. One theory is that prior to DNA and protein-based life there was an exclusively RNA-based world. Indeed, this theory is probably widely accepted as the most plausible, if not the only possible, scenario.

As I said, each theory has it's own problems, and the RNA-world theory is no different. The main difficulty is how to combine the three elements of an RNA molecule, i.e. the nucleobase, the ribose and the phosphate. In particular, attempts to join together the nucleobase and the ribose have always been met with failure, casting doubt on the likelihood of these molecules spontaneously combining in Earth's early atmosphere...

That is until now.

Phosphate continues to have several essential roles in the remaining steps of Powner and colleagues' pathway, in one case causing depletion of an undesired by-product, and in another saving a critical intermediate from degradation. The penultimate reaction of the sequence, in which the phosphate is attached to the nucleoside, is another beautiful example of the influence of systems chemistry in this set of interlinked reactions. The phosphorylation is facilitated by the presence of urea; the urea comes from the phosphate-catalysed hydrolysis of a by-product from an earlier reaction in the sequence.


This work represents a major breakthrough in our understanding of how life might have emerged as it has provided an elegant mechanism for the spontaneous generation of RNA. As always, more research needs to be done, but we now have an exciting new perspective on an age-old problem.


(1) Powner et al. Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature 459, 239-242 (14 May 2009)

(2) Jack W. Szostak. Origins of life: Systems chemistry on early Earth. Nature 459, 171-172 (14 May 2009)

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13 May, 2009

Did someone ask for transitional fossils?

A common claim by creationists is that there are 'no transitional fossils', despite advice from their own people to stop using this argument. These claims are often made in a blog or forum comment section rather than on an official website, since it is clearly a ludicrous statement. They also crop up a lot in comments on YouTube videos alongside such gems as 'If we evolved from monkeys, why are there still monkeys?'. (The mindset of the claimant is usually clear enough due to the accompanying derogatory statements about Barack Obama and/or homosexuals.)

Anyway back to my point, transitional fossils. This is one of my favourite photos:



Skull A is that of a modern day chimpanzee, the closest living relative to humans, which are represented by Skull N (Edit: For those who claim there is no proof of the relationship between humans and chimps, see here - prepare to be pwned). Since evolutionary theory predicts that humans and chimps share a common ancestor, there necessarily must have been hominid-like organisms in the past with intermediate morphologies between the two modern day species. Now look at all the other skulls. Pretty convincing evidence if you ask me. Here is a list of the species for each skull and the given dates for their ages:

(A) Pan troglodytes, chimpanzee, modern
(B) Australopithecus africanus, STS 5, 2.6 My
(C) Australopithecus africanus, STS 71, 2.5 My
(D) Homo habilis, KNM-ER 1813, 1.9 My
(E) Homo habilis, OH24, 1.8 My
(F) Homo rudolfensis, KNM-ER 1470, 1.8 My
(G) Homo erectus, Dmanisi cranium D2700, 1.75 My
(H) Homo ergaster (early H. erectus), KNM-ER 3733, 1.75 My
(I) Homo heidelbergensis, "Rhodesia man," 300,000 - 125,000 y
(J) Homo sapiens neanderthalensis, La Ferrassie 1, 70,000 y
(K) Homo sapiens neanderthalensis, La Chappelle-aux-Saints, 60,000 y
(L) Homo sapiens neanderthalensis, Le Moustier, 45,000 y
(M) Homo sapiens sapiens, Cro-Magnon I, 30,000 y
(N) Homo sapiens sapiens, modern

Evolutionists also disagree on how fossils should be classified, which species they belong to, etc. True enough. But according to evolutionary thinking, these fossils come from a number of closely related species intermediate between apes and humans. If this is so, we would expect to find that some of them are hard to classify, and we do. Creationists, on the other hand, assert that apes and humans are separated by a wide gap. If this is true, deciding on which side of that gap individual fossils lie should be trivially easy. Clearly, that is not the case.



Uploaded with ImageShack.us

Hat tip to BathTub

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11 May, 2009

The Dan Brown Code

Wanna know how to write a best seller and guarantee a movie deal?

Easy. Use the Dan Brown code:

Ageing Harvard professor
+ Attractive young female
- Murdered father who is brilliant scientist
+ European city
+ Famous landmarks
+ Trail of clues
+ Catholic church (great for pre-release controversy)
+ Secret society
+ Ruthless assassin working for mystery employers
- Loyalty from said mystery employers
+ Knowledgeable old disabled man
+ Race against time
+ Irrelevant romantic ending

= Cha-ching!! Several hundred million dollar profit

Class dismissed.

05 May, 2009

Nature review: Type I interferons and AIDS

Viruses have evolved highly effective mechanisms to manipulate the host immune response and facilitate replication. Following HIV infection in humans or simian immunodeficiency virus (SIV) infection in rhesus macaques, a chronic activation of the innate immune system is observed. This immune response is triggered by the recognition of viral RNA and DNA by members of the Toll-like receptor (TLR) family, specifically TLR7 and TLR9 on plasmacytoid dendritic cells (pDCs). These cells are also known as interferon (IFN)-producing cells due to the massive quantities of IFNa secreted following stimulation. One outcome of this chronic inflammation is a reduction in the regenerative ability of CD4+ T cells. This effect results in significant T cell depletion and is a major contributor to immunodeficiency associated with AIDS.

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01 May, 2009

Stupid Goddam Blasphemy Law

This is beyond ridiculous.

Dermot Ahern and the rest of the Fianna Fail bozos are actually considering bringing in a blasphemy law. If it's passed, a fine of up to €100,000 will be imposed on blasphemers.



This can't possibly be happening, can it? I mean, Jaysus, like, what's the problem...?